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Signal and Symptoms Podcast

Signal and Symptoms Podcast

By: Harvey Castro MD Junaid Kalia MD & Edward Marx
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Three healthcare AI experts who've watched millions wasted on failed projects. Dr. Harvey Castro, Dr. Junaid Kalia, Edward Marx, and guest experts cover all things healthcare AI - from digital transformation to clinical reality. Every Tuesday, we diagnose real failures, reveal what actually works, and help you avoid the expensive mistakes we've seen repeated everywhere. Because when AI decisions affect patient care, getting it right isn't optional.Copyright 2026 Harvey Castro MD, Junaid Kalia MD, & Edward Marx Hygiene & Healthy Living Physical Illness & Disease Politics & Government
Episodes
  • AI Won’t Replace Your Pediatrician — But It Will Change the Visit

    AI Won’t Replace Your Pediatrician — But It Will Change the Visit
    Jun 23 2026
    The hardest part of a pediatric visit now happens before the appointment even begins.In this episode, Dr. Isha Mannering — a board-certified pediatrician with 16 years in the Dallas–Fort Worth area and founder of InTuneMD — joins Dr. Junaid Kalia, Dr. Harvey Castro, and Ed Marx to confront a new reality in the exam room: parents arrive having already consulted TikTok and ChatGPT, and the physician’s first job is winning back trust. Drawing on more than a decade in practice and her decision to go independent, Isha makes the case for treating AI as a tool, not a takeover — one that can hand clinicians back their time, sharpen early-warning “signals” in young patients, and bring care into the home. The conversation widens into pediatric AI in practice, the rural-versus-frontier care divide, at-home sick care, and a blunt warning to health systems: enable entrepreneurship within your walls, or be disintermediated by those who will.What You Will Discover:Cold open + welcome (Junaid, Harvey, Ed + Dr. Mannering) Why trust is eroding: the viral-TikTok rare-disease scare AI as a tool: the “healthcare influencer” + scribe & signal Going independent: “figuring it out as I go” Authenticity: earning the trust of parents AND kids “Put the laptop down”: reclaiming the visit Pediatric AI in practice: comic discharge notes + an NFC plushie Catching the signal early: “never trust a newborn” At-home sick care: the 2 a.m. fever The hospital reckoning: adapt or be disintermediated Closing: human + AI — have fun with itReferenced in the show:🖇️ Dr. Harvey Castro’s work on ChatGPT in healthcare — https://www.harveycastromd.com/Connect with us:Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of SaveLife.AI™ 💼 LinkedIn — https://www.linkedin.com/in/junaidkaliamd 🔗 Website — https://www.junaidkalia.com/ 📹 YouTube — https://www.youtube.com/@junaidkaliamdDr. Harvey Castro, ER Physician, #DrGPT™ 💼 LinkedIn — https://www.linkedin.com/in/harveycastromd/ 🔗 Website — https://www.harveycastromd.com/ 📷 Instagram — https://www.instagram.com/harveycastromd/ 📑 Substack — https://harveycastromd.substack.com/Edward Marx, CEO, Advisor💼 LinkedIn — https://www.linkedin.com/in/edwardmarx/ 🔗 Website — https://www.marxadvisory.com/ 📹 YouTube — https://www.youtube.com/@EdwardMarxSpecial Guest:Dr. Isha Mannering, Board-Certified Pediatrician, Founder of InTuneMD 💼 LinkedIn — https://linkedin.com/in/drishaVisit our website: https://signalandsymptoms.com/Get advisory insights about Healthcare AI — at zero cost: https://junaidkaliamd.substack.com/Medical disclaimer: This conversation is for general informational purposes and is not medical advice. Listening does not create a doctor–patient relationship. Always consult a qualified clinician for your child’s care.
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    19 mins
  • How Brain Organoids Work (And Why They Could Replace Silicon)

    How Brain Organoids Work (And Why They Could Replace Silicon)
    Jun 9 2026
    The foundation of tomorrow's diagnostics is being rebuilt — and it starts in biology, not silicon.In this episode, Edmund White, biomedical innovator and bestselling author, joins the conversation to challenge an assumption quietly embedded in every AI tool entering healthcare: that silicon is the only material worth building on. Drawing from three decades at the intersection of cardiac care and medical innovation, Edmund traces a through-line from digital twins of children's hearts to brain organoids — arguing that biology's energy efficiency and adaptability aren't limitations to engineer around, they're the very properties that could unlock earlier intervention and more precise patient outcomes. The conversation widens from there into the economics of AI adoption, the coming bubble, and what it will take for healthcare systems and policymakers to get ahead of a shift that's already in motion.What You Will Discover:- Edmund's Journey From Cardiac Devices to Prevention- Brain Organoids Explained- Silicon vs. Biology: The Hybrid Computing Argument- What Happens When AI is Cheap and Effortless- The Social Impact of AI- Space Computing & Distributed Intelligence- Regulation, Policy, and Germany's Risk Aversion[16:30] Funding Priorities: Where Innovation Dollars Should GoReferenced in the show:🖇️ "AI Today: OI Tomorrow: The Dawn of Organoid Intelligence: Opportunities, Ethics, and the Future of Humanity" – https://www.amazon.com/AI-Today-Tomorrow-Intelligence-Opportunities/dp/1950043584 Connect with us:Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd🔗Website - https://www.junaidkalia.com/📹YouTube - https://www.youtube.com/@junaidkaliamdDr. Harvey Castro, ER Physician, #DrGPT™💼LinkedIn - https://www.linkedin.com/in/harveycastromd/🔗Website - https://www.harveycastromd.com/📷Instagram - https://www.instagram.com/harveycastromd/?hl=en📑 Substack - https://harveycastromd.substack.com/Edward Marx, CEO, Advisor💼LinkedIn - https://www.linkedin.com/in/edwardmarx/🔗Website - https://www.marxadvisory.com/📹YouTube - https://www.youtube.com/@EdwardMarxSpecial Guest:Edmund White, VP Business Development & Partnerships, AIBODY💼LinkedIn - https://www.linkedin.com/in/edmund-white-08362ab/🔗Website - https://www.ai2oi.com/Visit our website:https://signalandsymptoms.com/Get advisory insights about Healthcare AI — at zero cost:https://junaidkaliamd.substack.com/
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    19 mins
  • Why AI Isn't the Tech Hype Hospital Leaders Think It Is

    Why AI Isn't the Tech Hype Hospital Leaders Think It Is
    Jun 2 2026

    We built a healthcare system engineered for sick care, but the future of medicine belongs to those who seek health.

    In this episode, global Digital Health Futurist Philippe Gerwill joins the panel to unpack the real bottlenecks stalling clinical innovation. He highlights a critical inversion happening in modern medicine. Historically, technology lagged behind clinical needs. Today, advanced technology vastly outpaces our institutional capacity to adopt it. The conversation delivers an evidence-based perspective on how to manage this rapid acceleration from a global innovator who understands both big pharma infrastructure and the reality of clinical adoption.

    Tune in to discover how forward-thinking medical leaders are realigning systemic incentives to transition from algorithmic task managers back to true, humanist healers.

    What You Will Discover:

    - Intro: The Tech-Adoption Paradox

    - Human Bubble: From Tech Hype To Structural Adaptation

    - What AI and Quantum Convergence Mean for Medicine?

    - The Paradigm Shift from Sick Care to Seeking Health

    - Task Automation vs. Job Displacement

    - Is AI Getting Overwhelming?

    Connect with us:

    Dr. Junaid Kalia, Neurocritical Care Specialist and Founder of Savelife.AI™

    💼LinkedIn - https://www.linkedin.com/in/junaidkaliamd

    🔗Website - https://www.junaidkalia.com/

    📹YouTube - https://www.youtube.com/@junaidkaliamd

    Dr. Harvey Castro, ER Physician, #DrGPT™

    💼LinkedIn - https://www.linkedin.com/in/harveycastromd/

    🔗Website - https://www.harveycastromd.com/

    📷Instagram - https://www.instagram.com/harveycastromd/?hl=en

    📑 Substack - https://harveycastromd.substack.com/

    Edward Marx, CEO, Advisor

    💼LinkedIn - https://www.linkedin.com/in/edwardmarx/

    🔗Website - https://www.marxadvisory.com/

    📹YouTube - https://www.youtube.com/@EdwardMarx

    Special Guest:

    Philippe Gerwill, Digital Healthcare Humanist & Futurist

    💼LinkedIn - https://www.linkedin.com/in/philippegerwill/

    Visit our website:

    https://signalandsymptoms.com/

    Get advisory insights about Healthcare AI — at zero cost:

    https://junaidkaliamd.substack.com/

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    19 mins
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