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From First Principles

From First Principles

By: Krishna Choudhary and Lester Nare
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Summary

From First Principles is a fast, funny, and rigorous breakdown of the biggest science stories of the week, hosted by Lester Nare and physicist Krishna Choudhary, PhD. We go past headlines into the actual mechanics: what happened, why it matters, and what everyone’s missing. Expect physics, space, AI, energy, biotech, and the occasional “wait… is that real?” story. If you’re curious, skeptical, and you like learning in public — you’re in the right place.Krishna Choudhary and Lester Nare Science
Episodes
  • Dr. John Mulchaey on Carnegie Science and the Future of Astronomy (EP 41)
    May 13 2026

    Hosted by Lester Nare and Krishna Choudhary, this interview features John Mulchaey, the 12th President of Carnegie Science and former Director of the Carnegie Observatories. The conversation starts with his early work on galaxy groups and dark matter, then expands into how Carnegie works as a scientific institution, what the Giant Magellan Telescope could unlock for exoplanets and astronomy, how science funding actually works, and why eclipse chasing is still one of the most magical experiences in science.

    Summary

    Galaxy groups and dark matter — Mulchaey explains why small galaxy groups matter more than most people realize, and how X-ray observations of hot gas helped make their masses measurable.

    Carnegie’s model — the interview gets into what makes Carnegie unusual: scientific freedom, long time horizons, and room to pursue surprising questions.

    The Giant Magellan Telescope — a look at why bigger telescopes matter, what GMT changes, and why exoplanet atmospheres are one of the biggest goals ahead.

    The bigger picture — science funding, philanthropy, how astronomy has changed, and why total solar eclipses still inspire so many astronomers.

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    Show NotesJohn Mulchaey leadership bio — Carnegie Sciencehttps://carnegiescience.edu/about/leadershipCarnegie Science appoints John Mulchaey as its 12th Presidenthttps://carnegiescience.edu/news/carnegie-science-appoints-john-mulchaey-its-12th-presidentGiant Magellan Telescope — official overviewhttps://giantmagellan.org/about-us/1993 NASA write-up on Mulchaey’s dark matter result in galaxy groupshttps://science.nasa.gov/missions/hubble/dark-matter-found-in-a-typical-cluster-of-galaxies/Carnegie Science Great North American Eclipse outreach recaphttps://carnegiescience.edu/yearbook/2024/science/great-north-american-eclipsePerot Museum eclipse partnership recaphttps://www.perotmuseum.org/events/solar-eclipses/

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    37 mins
  • Ant Scans, Lunar Chickpeas, Hidden Galaxies & Superconductivity (EP 40)
    Apr 29 2026

    Hosted by Lester Nare and Krishna Choudhary, this rundown episode covers four new science stories at a high level: a huge new 3D ant imaging database built with synchrotron X-ray microtomography, a lunar agriculture experiment that grew chickpeas in simulated moon soil using fungi and worm waste, AI-assisted discovery of strange objects in the Hubble archive, and a new programmatic roadmap for room-temperature superconductivity. There is also another round of Are You Smarter Than a Scientist? in the middle.


    Summary


    Particle accelerators meet biodiversity — researchers built a massive high-resolution ant imaging resource, covering nearly 800 species and thousands of specimens, with AI-assisted 3D reconstruction.


    Moon farming gets weird — chickpeas were grown in lunar regolith simulant with help from mycorrhizal fungi and worm-derived compost, a first step toward sustainable off-world agriculture.


    AI found hidden anomalies in Hubble’s archive — AnomalyMatch sifted through roughly 100 million source cutouts in just days and surfaced new candidate lenses, mergers, and other rare objects.


    The superconductivity long game — a new PNAS perspective argues that room-temperature superconductivity is not ruled out by physics, and calls for a coordinated push to get there.

    Support the show
    Donate: FFPod.com/donate
    Follow: @FFPod on X / Instagram / TikTok / Facebook


    Show Notes

    High-throughput phenomics of global ant biodiversity — Nature Methods

    Bioremediation of lunar regolith simulant through mycorrhizal fungi and plant symbioses enables chickpea to seed — Scientific Reports

    Identifying astrophysical anomalies in 99.6 million source cutouts from the Hubble legacy archive using AnomalyMatch — Astronomy & Astrophysics

    The path to room-temperature superconductivity: A programmatic approach — PNAS

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    37 mins
  • The Prometheus Constellation: Dramaturgical and Scientific Analysis of the Physicists in Oppenheimer (EP 39)
    Apr 21 2026

    Hosted by Lester Nare and Krishna Choudhary, this special episode ranks the 26 scientists shown in Christopher Nolan’s Oppenheimer by one standard only: their contribution to fundamental science. Starting with the Manhattan Project figures near the bottom and working up through the giants of quantum mechanics, relativity, nuclear physics, and logic, the episode turns a movie cast list into a surprisingly deep walk through the history of modern physics.


    Summary


    A ranking framework that actually means something — this list is based on scientific achievement, not movie prominence, clout, or vibes.


    A tour of 20th-century science — from nuclear chain reactions and black holes to MRI, GPS, quantum mechanics, and information theory.


    The great debates — several placements are designed to provoke real argument, especially around how Oppenheimer compares to the physicists around him.


    A top tier full of monsters — the back half of the episode becomes a speedrun through some of the most influential scientific minds of the modern era.


    Support the show
    Donate: FFPod.com/donate
    Follow: @FFPod on X / Instagram / TikTok / Facebook

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    1 hr and 37 mins
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